Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1
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منابع مشابه
Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1
Proteasomes are essential for protein homeostasis in eukaryotes. To preserve cellular function, transcription of proteasome subunit genes is induced in response to proteasome dysfunction caused by pathogen attacks or proteasome inhibitor drugs. In Caenorhabditis elegans, this response requires SKN-1, a transcription factor related to mammalian Nrf1/2. Here, we use comprehensive genetic analyses...
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ژورنال
عنوان ژورنال: eLife
سال: 2016
ISSN: 2050-084X
DOI: 10.7554/elife.17721